Trained Immunity-based Vaccines in El Escorial Summer Courses

Trained Immunity-based Vaccines in El Escorial Summer Courses

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07/2019. El Escorial Summer Course: Trained Immunity-based Vaccines

Trained Immunity-based Vaccines (TIbV) represent a conceptually important advance as they open new avenues to vaccine design against recurrent infections that are difficult to prevent. In the summer course “Trained immunity-based vaccines: the innate immune memory working towards  antiinfectious immunotherapy” this topic has been addressed from the most basic aspects to the potential clinical relevance. 

The course, conducted under the direction of Dr. Silvia Sánchez-Ramón (Head of the Immunology Service of the San Carlos Hospital, Madrid) and Dr. Laura Conejero Hall (Medical Dept. of INMUNOTEK) as Scientific Secretariat, and coordinated by Prof. Eduardo Martínez-Naves (Complutense University of Madrid), has brought to different experts in basic and clinical research in the field, and an outstanding audience.  

Trained immunity is the ability of innate immune cells to act with a certain immune memory, something that, until very recently, was only thought that adaptive immunity could do. “The description that the cells of the innate immune system are able to remember past stimuli to generate more potent responses is a revolutionary paradigm shift”, said Dr. Jorge Dominguez, a researcher at the Radboud Institute for Molecular Life Science (RIMLS) of Holland.

“The potential is enormous. The application of trained immunity will improve the responses of existing vaccines, help the creation of new ones, more effective in time, as well as allow the formulation of new therapies against various diseases such as cancer” , Dr. Dominguez said.

Course schedule

 

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Immunomodulatory effect of oral epithelial cells

Immunomodulatory effect of oral epithelial cells

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07/2019. Immunomodulation by oral epithelial cells

The oral mucosa is subject to a constant exposure of foreign substances such as food and microorganisms that make up its flora. Understanding the mechanisms that operate to avoid inflammatory reactions has been one of the objectives of the work recently published in Frontiers in Immunology.

This research work, led by Prof. Pedro Reche (School of Medicine, Complutense University of Madrid), highlights the important regulatory role of epithelial cells in the oral cavity. These cells were shown to prevent the full maturation of dendritic cells (DC)  while exert a strong suppressor effect on T cells. As a stimulus for DC activation and maturation, a cocktail of bacteria (MV130) provided by INMUNOTEK was used. The activation pathways induced by MV130 on DC were known from previous studies.

  

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INMUNOTEK at the EAACI congress

INMUNOTEK at the EAACI congress

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06/2019. INMUNOTEK at the EAACI

INMUNOTEK has been present at the annual conference of the EAACI (European Academy of Allergy and Clinical Immunology) held in Lisbon.

With more than 7,000 delegates, the EACCI congress, held at the International Fair of Lisbon, from June 1 to 4, is one of the most important events in the world in the field of allergy and clinical immunology.

INMUNOTEK has actively participated commercially and scientifically. Many allergists from the five continents interested in its products have gone through their stand, especially in the new developments of vaccines targeting dendritic cells. As in other years, there have been demonstrations of the Prick-Film system that have attracted a large number of visitors.


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The olive tree protagonist in the “Eliseo Subiza” Botanical Day

The olive tree protagonist in the “Eliseo Subiza” Botanical Day

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05/2019. Eliseo Subiza Botanical Identification Days

The XXII Botanical Identification Day “Eliseo Subiza” was dedicated to the olive tree.

These days, organized by the Allergy Service of the “Virgen del Valle” Hospital and the AINALVIVA (Association for the Allergological Research Virgen del Valle) of Toledo, have dedicated their XXII edition to the olive tree. The pollen of this tree is of great allergological importance in Spain and other Mediterranean countries where this tree abounds. Its pollen produces respiratory allergies with a high prevalence in the South of Europe. In addition to the field trips around Toledo to learn about allergenic plants, a visit was made to the Olive Oil Museum “Felipe Vegue” de Mora and the olive grove of the “La Moncloa” farm in Mascaraque (Toledo).

The “Eliseo Subiza” Botanical Identification Days emerged as an initiative of Dr. Carlos Senent (Allergy Service of the Virgen del Valle Hospital, Toledo, Spain) to promote the botanical knowledge among young allergists to become familiar with the main allergenic local plants. The training is eminently practical with field trips guided by botanical experts, which are complemented by lectures on aeroallergens, botany, palynology and aerobiology. They carry the name of the allergist Eliseo Subiza (1921-1998) in recognition of his pioneering work in the study of allergenic pollens in Spain.

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Tonsil surgery is reduced with Bactek-MV130

Tonsil surgery is reduced with Bactek-MV130

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04/2019. Bactek-MV130 reduces tonsillectomies

According to a recent study published in the scientific journal Human Vaccines & Immunotherapeutics by Luis-Amando García González and Federico Arrutia Díez, the combination of an antibiotic treatment with Bactek-MV130 significantly reduces the need of tonsils removal in adult patients with recurrent tonsillitis.

The study, conducted at Hospital Valle del Nalón and Hospital de Cabueñes (Asturias, Spain) over 88 patients, compared a group treated with antibiotics alone to another treated with antibiotics plus Bactek-MV130.

Bactek-MV130 is a polybacterial mucosal vaccine produced by INMUNOTEK that is administered sublingually. Bactek-MV130 acts as a TIbV (trained immunity-based vaccine).  These vaccines may confer a broad anti-infectious protection, as outlined recently in Frontiers in Immunology.

Download the article

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Visit of the Regional Minister of Health

Visit of the Regional Minister of Health

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03/2019. The Regional Minister of Health visits INMUNOTEK

The Regional Minister of Health of the Community of Madrid, Enrique Ruiz Escudero, visited the facilities of INMUNOTEK in Tecnoalcalá (Alcalá de Henares – Madrid). 

On March 15, the Regional Minister of Health of the Community of Madrid, Enrique Ruiz Escudero, visited INMUNOTEK after being awarded the prize for the best Innovative Company granted by CEIM-CEOE.

José Luis Subiza, CEO-President, made a brief presentation of the company and the R&D projects that INMUNOTEK is developing in collaboration with different hospitals and centers in the Community of Madrid. He highlighted the research lines that the company has in immunotherapy for allergic, infectious and neoplastic diseases. He took the opportunity to present the INMUNOTEK Foundation, recently created, and its main objectives. Then, they made a tour to the production facilities, in order to learn about the manufacturing processes and control of their products.

The visit was accompanied by Luisa María Fernández, General Director of Madrid Activa, the public management company of Tecnoalcalá, and the managers of INMUNOTEK.


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INMUNOTEK revalidates its Innovative SME stamp

INMUNOTEK revalidates its Innovative SME stamp

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03/2019. Innovative SME stamp

INMUNOTEK revalidates its Innovative SME stamp.

INMUNOTEK maintains its R&D effort working in a number of research projects that have allowed the revalidation of the Innovative SME stamp granted in 2015 by the Spanish Government.

Currently, INMUNOTEK has ongoing projects with different research centers, including the Complutense University of Madrid (Immunology, Biochemistry and Cell Biology), University of Salamanca, CNIC (National Center for Cardiovascular Research), ISCIII (Carlos III Health Institute) and CIB (Biological Research Center).

The public record of innovative SMEs depends on the Directorate for Innovation and Competitiveness of the Ministry of Economy and Competitiveness of Spain. It is granted by the Order ECC / 1087/2015 where the requirements for its obtention are described.

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INMUNOTEK Awards

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TIbV – Trained Immunity-based Vaccines

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iGEM 2018 competition

iGEM 2018 competition

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11/2018. The iGEM-Madrid team awarded

The project presented by the iGEM-Madrid team has been awarded with a silver medal and nominated as the best project of its category in the iGEM 2018 competition held in Boston. 

The iGEM competition originated in 2003 at the Massachusetts Institute of Technology in order to encourage the development of biosynthetic applications among students and recent graduates. At present, this competition has an international dimension with the participation of hundreds of teams from more than 40 countries.

This year a team from Madrid (iGEM-Madrid) has been presented for the first time, made up of students and recent graduates from various faculties of the Complutense University of Madrid. His project IoBT (Internet of Bio-Things) is an integration of engineering, biosensors and data transfer in real time over the internet for the quantification of allergens in the air of cities. His prototype has earned recognition in the competition held in Boston where more than 300 teams from all over the world have performed.

The iGEM-Madrid team has been sponsored by INMUNOTEK.

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The iGEM-Madrid team: Francisco Javier Quero Lombardero, Laura Armero Hernandez, Rodrigo Hernández Cifuentes, Iván Martín Hernández, Borja Sánchez Clemente, Ignacio Albert Smet, Guillermo Fernández Rodríguez, Gonzalo Saiz Gonzalo. 

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